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Worldwide HLA-E nucleotide and haplotype variability reveals a conserved gene for coding and 3′ untranslated regions.
- Source :
- Tissue Antigens; Feb2014, Vol. 83 Issue 2, p82-93, 12p
- Publication Year :
- 2014
-
Abstract
- The human leukocyte antigen-E ( HLA-E) locus is a human major histocompatibility complex ( MHC) gene associated with immune-modulation and suppression of the immune response by the interaction with specific natural killer ( NK) and T cell receptors (TCRs). It is considered one of the most conserved genes of the human MHC; however, this low nucleotide variability seems to be a consequence of the scarce number of studies focusing on this subject. In this manuscript we assessed the nucleotide variability at the HLA-E coding and 3′ untranslated regions (3′UTRs) in Brazil and in the populations from the 1000Genomes Consortium. Twenty-eight variable sites arranged into 33 haplotypes were detected and most of these haplotypes (98.2%) are encoding one of the two HLA-E molecules found worldwide, E*01:01 and E*01:03. Moreover, three worldwide spread haplotypes, associated with the coding alleles E*01:01:01, E*01:03:01 and E*01:03:02, account for 85% of all HLA-E haplotypes, suggesting that they arose early before human speciation. In addition, the low nucleotide diversity found for the HLA-E coding and 3′ UTR in worldwide populations suggests that the HLA-E gene is in fact a conserved gene, which might be a consequence of its key role in the modulation of the immune system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00012815
- Volume :
- 83
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Tissue Antigens
- Publication Type :
- Academic Journal
- Accession number :
- 93876744
- Full Text :
- https://doi.org/10.1111/tan.12283