Dopamine transporter imaging with [123I]FP-CIT (DaTSCAN) in Parkinson's disease with depressive symptoms: a biological marker for causal relationships?

The article presents the authors views on finding causal relationship between Parkinson's disease (PD) with depressive symptoms by dopamine transporter (DaT) imaging with iodine-123-fluoropropyl (FP)-carbomethoxy-3 β-(4-iodophenyltropane) (CIT). He states that motor impairment assessed by the Unified Parkinson's Disease Rating Scale part III (UPDRS-III) and depressive symptoms assessed by the Beck Depression Inventory (BDI) both correlated negatively with DaT uptake.