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CTLA-4: new insights into its biological function and use in tumor immunotherapy.
- Source :
- Nature Immunology; Jul2002, Vol. 3 Issue 7, p611, 8p
- Publication Year :
- 2002
-
Abstract
- The discovery of multiple costimulatory cell surface molecules that influence the course oft cell activation has increased our appreciation of the complexity of the T cell response. It remains clear, however, that CD28 and cytotoxic T lymphocyte antigen 4 (CTLA-4) are the critical costimulatory receptors that determine the early outcome of stimulation through the T cell antigen receptor (TCR). Details of how the T cell integrates TCR stimulation with the costimulatory signals of CD28 and the inhibitory signals of CTLA-4 remain to be established, but unique features of the cell biology of CTLA-4 provide important insights into its function. We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses. We also describe preclinical and clinical results that indicate manipulation of CTLA-4 has considerable promise as a strategy for the immunotherapy of cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cell receptors
ANTIGENS
TUMOR immunology
IMMUNOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 3
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9431914
- Full Text :
- https://doi.org/10.1038/ni0702-611