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Taurine deficiency after intensive chemotherapy and/or radiation.
- Source :
- American Journal of Clinical Nutrition; Mar1992, Vol. 55 Issue 3, p708-711, 4p
- Publication Year :
- 1992
-
Abstract
- Taurine, a nonessential amino acid (AA), is the most abundant free AA in the intracellular space. We measured plasma AA concentrations in 36 patients 7-28 d after intensive chemotherapy and/or radiation. Plasma taurine concentrations were uniformly low in all patients (20.0 ± 6.4 L, ... ± SD). Plasma taurine in 11 healthy volunteer control subjects was 45.0 ± 20.3 (P < 0.001). Other AA concentrations, specifically those of precursor AAs methionine and cystine, were normal. We prospectively measured plasma AA concentrations in 12 patients before starting and 6-10 d after completing intensive cytotoxic treatment. Values before treatment were 37.2 ± 1 1.6, 109.6 ± 30.7, and 18.5 ± 4.8 for taurine, cystine, and methionine, respectively, and were 24.3 ± 6.0, 1 11.2 ± 23.8, and 24.0 ± 14.5 after treatment. Pretreatment plasma taurine correlated directly with the magnitude of decrease in plasma taurine during cytotoxic treatment (n = 12, r = 0.85, P < 0.01). Intensive cytotoxic chemotherapy and/or radiation leads to a reduction in plasma taurine concentrations without any change in its precursor AAs, methionine and cystine. The clinical relevance of plasma taurine depletion will need further study. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 55
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 94402398
- Full Text :
- https://doi.org/10.1093/ajcn/55.3.708