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Performance of Shear Wave Elastography for Differentiation of Benign and Malignant Solid Breast Masses.

Authors :
Li, Guiling
Li, De-Wei
Fang, Yu-Xiao
Song, Yi-Jiang
Deng, Zhu-Jun
Gao, Jian
Xie, Yan
Yin, Tian-Sheng
Ying, Li
Tang, Kai-Fu
Source :
PLoS ONE; Oct2013, Vol. 8 Issue 10, p1-8, 8p
Publication Year :
2013

Abstract

Objectives: To perform a meta-analysis assessing the ability of shear wave elastography (SWE) to identify malignant breast masses. Methods: PubMed, the Cochrane Library, and the ISI Web of Knowledge were searched for studies evaluating the accuracy of SWE for identifying malignant breast masses. The diagnostic accuracy of SWE was evaluated according to sensitivity, specificity, and hierarchical summary receiver operating characteristic (HSROC) curves. An analysis was also performed according to the SWE mode used: supersonic shear imaging (SSI) and the acoustic radiation force impulse (ARFI) technique. The clinical utility of SWE for identifying malignant breast masses was evaluated using analysis of Fagan plot. Results: A total of 9 studies, including 1888 women and 2000 breast masses, were analyzed. Summary sensitivities and specificities were 0.91 (95% confidence interval [CI], 0.88–0.94) and 0.82 (95% CI, 0.75–0.87) by SSI and 0.89 (95% CI, 0.81–0.94) and 0.91 (95% CI, 0.84–0.95) by ARFI, respectively. The HSROCs for SSI and ARFI were 0.92 (95% CI, 0.90–0.94) and 0.96 (95% CI, 0.93–0.97), respectively. SSI and ARFI were both very informative, with probabilities of 83% and 91%, respectively, for correctly differentiating between benign and malignant breast masses following a “positive” measurement (over the threshold value) and probabilities of disease as low as 10% and 11%, respectively, following a “negative” measurement (below the threshold value) when the pre-test probability was 50%. Conclusions: SWE could be used as a good identification tool for the classification of breast masses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
10
Database :
Complementary Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
94478295
Full Text :
https://doi.org/10.1371/journal.pone.0076322