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A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses.
- Source :
- PLoS Computational Biology; Feb2014, Vol. 10 Issue 2, p1-14, 14p, 3 Charts, 8 Graphs
- Publication Year :
- 2014
-
Abstract
- Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo. [ABSTRACT FROM AUTHOR]
- Subjects :
- BAYESIAN analysis
GENETIC mutation
ZOONOSES
SIMIAN immunodeficiency virus
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 10
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 94728948
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1003493