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THE STUDY OF HIV INFECTION IN CHINESE ANTIRETROVIRAL THERAPY PATIENTS.
- Source :
- Journal of Biological Systems; Mar2014, Vol. 22 Issue 1, p73-88, 16p
- Publication Year :
- 2014
-
Abstract
- Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insights into the dynamics of human immunodeficiency virus type 1. We built a simple mathematics model to study the effect of latent-infected resting memory CD4+ T cells during the HIV infection and highly active anti-retroviral therapy (HAART). Through analysis of eight patients who received HAART in China, we have an insight into the mechanisms of resting memory CD4+ T cells in HIV infection. Simulations show that new infections still exist in the eight patients even under the HAART. Also, because of the long half-life of resting infected memory CD4+ T cells, removal of HIV from patient could take considerably longer time or be unattainable. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02183390
- Volume :
- 22
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Biological Systems
- Publication Type :
- Academic Journal
- Accession number :
- 94756915
- Full Text :
- https://doi.org/10.1142/S0218339014500041