Back to Search
Start Over
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo.
- Source :
- Nature Immunology; Mar2002, Vol. 3 Issue 3, p265, 7p
- Publication Year :
- 2002
-
Abstract
- The rational design of vaccines that elicit CD8<superscript>+</superscript> T cell responses requires knowledge of the identity of the antigen-presenting cell (APC), the location and time of presentation and the nature of the antigen presented by the APC. Here we address these questions for an antigen encoded by a recombinant vaccinia virus. We found that, following local infection, vaccinia virus infected macrophages and dendritic cells in draining lymph nodes. However, only the dendritic cells presented antigen to naïve CD8<superscript>+</superscript> T cells, as determined by direct visualization of sectioned nodes by confocal microscopy. Presentation occurred as rapidly as 6 h after inoculation and quickly declined in parallel with the number of infected cells present in the nodes. These data provide direct evidence that virus-infected APCs prime naïve CD8<superscript>+</superscript> T cells in vivo. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
DENDRITIC cells
VACCINES
IMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 3
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9511876
- Full Text :
- https://doi.org/10.1038/ni762