Organocatalytic Synthesis of Terminal Propargylamine Derivatives by Tandem Amination-Alkynylation.

Authors :: Wang, Yu
Peng, Fangzhi
Zhang, Hongbin
Shao, Zhihui
Source :: Synlett; 2009, Issue 20, p3287-3290, 4p
Publication Year :: 2009
Abstract: The first organocatalytic synthesis of terminal propargylic amines from aldehydes via tandem amination/Seyferth-�Gilbert alkynylation has been developed. The described protocol provides the formal addition products of acetylene (HC≡CH) to ali�phatic imines, which are not easily obtained directly. [ABSTRACT FROM AUTHOR]

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