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The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions.
- Source :
- PLoS ONE; Mar2014, Vol. 9 Issue 3, p1-10, 10p
- Publication Year :
- 2014
-
Abstract
- Migratory CD103<superscript>+</superscript> and lymphoid-resident CD8<superscript>+</superscript> dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional diversity of the two DC types is nevertheless incompletely understood. Here we reveal that upon skin infection with herpes simplex virus, migratory CD103<superscript>+</superscript> DCs from draining lymph nodes were more potent at inducing Th17 cytokine production by CD4<superscript>+</superscript> T cells than CD8<superscript>+</superscript> DCs. This superior capacity to drive Th17 responses was also evident in CD103<superscript>+</superscript> DCs from uninfected mice. Their differential potency to induce Th17 differentiation was reflected by higher production of IL-1β and IL-6 by CD103<superscript>+</superscript> DCs compared with CD8<superscript>+</superscript> DCs upon stimulation. The two types of DCs from isolated lymph nodes also differ in expression of certain pattern recognition receptors. Furthermore, elevated levels of GM-CSF, typical of those found in inflammation, substantially increased the pool size of CD103<superscript>+</superscript> DCs in lymph nodes and skin. We argue that varied levels of GM-CSF may explain the contrasting reports regarding the positive role of GM-CSF in regulating development of CD103<superscript>+</superscript> DCs. Together, we find that these two developmentally closely-related DC subsets display functional differences and that GM-CSF has differential effect on the two types of DCs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 95436202
- Full Text :
- https://doi.org/10.1371/journal.pone.0091126