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Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction.
- Source :
- European Journal of Clinical Pharmacology; May2014, Vol. 70 Issue 5, p527-530, 4p, 2 Graphs
- Publication Year :
- 2014
-
Abstract
- Purpose: Ischemia/reperfusion injury remains an untreated clinical problem in patients with acute myocardial infarction (AMI) despite significant advances in emergent revascularization through percutaneous coronary intervention (PCI). Pharmacological intervention for infarct size reduction is unavailable. We have identified that the medications milrinone and esmolol, when administered together at the beginning of the reperfusion, significantly decrease infarct size via reducing reperfusion injury in an experimental model. The present study tested the safety of combination therapy of milrinone and esmolol (M + E) in patients with AMI. Methods: Sixteen subjects with AMI requiring PCI were consecutively recruited. M + E was intravenously infused simultaneously for 10 min started at 5 min before anticipated angioplasty balloon inflation. Another 16 consecutively recruited AMI patients requiring PCI served as a placebo arm treated per routine clinical protocol. Blood pressure (BP) and heart rate (HR) were monitored continuously during PCI. Results: M + E combination therapy resulted in a trend of non-significant reduction in BP compared with a control group. There was a modest but significant increase in HR at the later phase of M + E infusion compared with a control group. No significant cardiac arrhythmia was induced during M + E infusion. Conclusions: The combination therapy with M + E produces a minimal change in hemodynamics and appears safe as an adjunctive therapy to PCI in AMI patients. Further studies are warranted. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADRENERGIC beta agonists
SYMPATHOLYTIC agents
MILRINONE
ANALYSIS of variance
COMBINATION drug therapy
CHI-squared test
HEMODYNAMICS
INTRAOPERATIVE care
MYOCARDIAL infarction
MYOCARDIAL reperfusion complications
MYOCARDIAL revascularization
HEALTH outcome assessment
REGRESSION analysis
RESEARCH funding
TRANSLUMINAL angioplasty
PILOT projects
TREATMENT effectiveness
REPEATED measures design
ACUTE diseases
DATA analysis software
DESCRIPTIVE statistics
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00316970
- Volume :
- 70
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- European Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 95446662
- Full Text :
- https://doi.org/10.1007/s00228-014-1650-9