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Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines.
- Source :
- Cancer Vaccines: Methods & Protocols; 2014, p155-165, 11p
- Publication Year :
- 2014
-
Abstract
- Invariant natural killer T cells (iNKT) and dendritic cells (DC) play a central role in tumor immunity through downstream activation of immune effector cells by pro-inflammatory cytokines. Evidence is accumulating that the CD1d-iNKT cell axis can be effectively used to potentiate DC-based cancer vaccines. Here, we provide a detailed methodology for the generation of (CD1d-expressing) monocyte-derived DC (moDC) and their subsequent loading with the iNKT cell agonist α-galactosylceramide (α-GalCer) or their direct ligation by agonistic anti-CD1d monoclonal antibodies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9781493903443
- Database :
- Complementary Index
- Journal :
- Cancer Vaccines: Methods & Protocols
- Publication Type :
- Book
- Accession number :
- 95557026
- Full Text :
- https://doi.org/10.1007/978-1-4939-0345-0_14