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Surgical treatment for pulmonary pleomorphic carcinoma: A retrospective study of 60 patients.
- Source :
- Thoracic Cancer; May2014, Vol. 5 Issue 3, p250-254, 5p
- Publication Year :
- 2014
-
Abstract
- Background Pleomorphic carcinoma is a rare epithelial malignant tumor. Because the clinical characteristics and behavior of the disease remain unclear, we investigated the clinicopathological findings and prognosis of 60 patients with pleomorphic carcinoma. Methods The clinicopathological characteristics of 60 cases of pulmonary pleomorphic carcinoma identified between 1999 and 2011 were studied. Of these, 55 patients had peripheral disease and five had central disease. The tumor size in all patients was 1-9.5 cm (mean, 5.8 ± 4.5 cm), while 30 had lesions with a diameter larger than 5 cm. All patients underwent pulmonary resection. Results There were no in-hospital deaths. The three and five year survival rates of all patients were 47.2% and 25.6%, respectively. The three and five year survival rates were 57.3% and 32.5% for N0 patients, and 25.4% and 17.1% for N1-2 patients, respectively. Overall survival was significantly different between the radical resection and incomplete resection groups. Multivariate Cox regression analyses of overall survival for all 60 patients indicated that radical resection ( P = 0.041), tumor node metastasis ( TNM) stage ( P = 0.044), and nodal status ( P = 0.029) were significant independent prognostic factors. Conclusion Pleomorphic carcinoma is a rare type of lung cancer. In our study, pleomorphic carcinoma of the lung was often found as a peripherally located large mass and was associated with a poor prognosis. Radical resection, TNM stage and nodal status were significant independent prognostic factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- THORACIC surgery
ACADEMIC medical centers
BIOPSY
CONFIDENCE intervals
DIAGNOSTIC imaging
LONGITUDINAL method
LUNG tumors
MEDICAL records
MULTIVARIATE analysis
HEALTH outcome assessment
REGRESSION analysis
SURVIVAL
TREATMENT effectiveness
PROPORTIONAL hazards models
RETROSPECTIVE studies
DATA analysis software
DESCRIPTIVE statistics
KAPLAN-Meier estimator
LOG-rank test
Subjects
Details
- Language :
- English
- ISSN :
- 17597706
- Volume :
- 5
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Thoracic Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 95683372
- Full Text :
- https://doi.org/10.1111/1759-7714.12086