Multiple Metachronous Osteosarcomas in a Patient with Li-Fraumeni Syndrome.

The article presents a case study which examines the prevalence of multiple metachronous osteosarcomas in Li-Fraumeni syndrome (LFS) patient. It mentions that the patient in the study had a family history of cancer with bilateral breast cancer and pelvic chondrosarcoma. The case suggests that some metachronous osteosarcomas are second primaries not metastases.