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The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.
- Source :
- FEBS Letters; May2014, Vol. 588 Issue 9, p1666-1672, 7p
- Publication Year :
- 2014
-
Abstract
- Highlights: [•] SNP rs1143684 results in either a Phe or Leu at position 47 in human NQO2. [•] NQO2-L47 has a slightly lower k <subscript>cat</subscript>/K <subscript>m</subscript>; it also has a lower K <subscript>i,app</subscript> with resveratrol. [•] NQO2-L47 is more unstable to proteolysis and thermal denaturation. [•] NQO2-F47 (but not NQO2-L47) shows negative cooperativity towards resveratrol. [•] NQO2-L47 exists as multiple conformers in solution. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 588
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95813787
- Full Text :
- https://doi.org/10.1016/j.febslet.2014.02.063