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Preparation and characterisation of andrographolide niosomes and its anti-hepatocellular carcinoma activity.
- Source :
- Journal of Microencapsulation; Jun2014, Vol. 31 Issue 4, p307-316, 10p
- Publication Year :
- 2014
-
Abstract
- Objective: In this study, a novel andrographolide (AG) preparation formulation, niosomes, was prepared to improve the bioavailability and tissue distribution of AG. Methods: The niosomal formulation of AG was prepared by film hydration/sonication method and tissue distribution was measured by liquid chromatography-mass spectrometry (LC-MS) method in mice, and anti-hepatocellular carcinoma (anti-HCC) activity was examined by MTT method in HepG2. Results: Entrapment efficiency, drug-loading ratio and average particle size of AG niosomes were 72.36%, 5.90% and 206 nm, respectively. The tissue distribution in mice demonstrated that the AG niosomes were absorbed in liver much more than the free AG. Furthermore, the anti-HCC activity in HepG2 cells showed that there was no significant difference between free AG and AG niosomes. Conclusion: The present results suggest that AG niosomes may have a significant potential of liver targeting, which is valuable in chemotherapy of HCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02652048
- Volume :
- 31
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Microencapsulation
- Publication Type :
- Academic Journal
- Accession number :
- 96150749
- Full Text :
- https://doi.org/10.3109/02652048.2013.843727