Synthesis of a New Class of Strongly Antibacterial Heterocyclic Compounds: 8-Bromo-6-alkyl-1-aryl-6 H-isoxazolo[4,3- E]indoles.

The synthesis, spectral characterization, and antibacterial activity of some new substituted 8-bromo-6-alkyl-isoxazolo[4,3- e]indoles are presented. Their antibacterial activity (MIC) against methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) were determined . The results revealed that compounds 3e-3h displayed greater antibacterial activity against MRSA than did the well-known antibacterial agents cephalexin and erythromycin. [ABSTRACT FROM AUTHOR]