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Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis.
- Source :
- Frontiers in Immunology; May2014, Vol. 5, p1-6, 6p
- Publication Year :
- 2014
-
Abstract
- Prophylactic approaches to graft versus host disease (GvHD) have employed both phenotypic reduction of T cells and selective elimination of host-primed donor T cells in vitro and in vivo. An additional approach to GvHD prophylaxis by functional depletion of apoptosis-sensitive donorT cells without host-specific sensitization ex vivo showed remarkable reduction in GHD incidence and severity.We address the role and significance of antigen-specific sensitization of donor T cells and discuss the mechanisms of functional T cell purging by apoptosis for GvHD prevention. Host-specific sensitization is dispensable because migration is antigen-independent and donor T cell sensitization is mediated by multiple and redundant mechanisms of presentation of major and minor histocompatibility complex and tissue antigens by donor and host antigen-presenting cells. Our data suggest that potential murine and human GvH effectors reside within subsets of preactivated T cells susceptible to negative regulation by apoptosis prior to encounter of and sensitization to specific antigens. [ABSTRACT FROM AUTHOR]
- Subjects :
- GRAFT versus host disease
T cells
APOPTOSIS
IMMUNOGLOBULINS
IMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 5
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 96381037
- Full Text :
- https://doi.org/10.3389/fimmu.2014.00215