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Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.
- Source :
- Emerging Themes in Epidemiology; 2014, Vol. 11, p1-23, 23p, 2 Diagrams, 1 Chart
- Publication Year :
- 2014
-
Abstract
- Background The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings. Objective To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents. Methods A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE. Results Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with nonatopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects. Conclusions More research using standardized methodology is needed on the causes of non-atopic asthma. [ABSTRACT FROM AUTHOR]
- Subjects :
- ASTHMA risk factors
BREASTFEEDING
CONFIDENCE intervals
MEDICINE
OBESITY
RESEARCH funding
RESPIRATORY infections
RESPIRATORY organ sounds
SYSTEMATIC reviews
EVIDENCE-based medicine
PROFESSIONAL practice
HOME environment
SOCIAL context
FAMILY history (Medicine)
ODDS ratio
ADOLESCENCE
CHILDREN
HISTORY
Subjects
Details
- Language :
- English
- ISSN :
- 17427622
- Volume :
- 11
- Database :
- Complementary Index
- Journal :
- Emerging Themes in Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 97173519
- Full Text :
- https://doi.org/10.1186/1742-7622-11-5