Copper(I)-Catalyzed Decarboxylative Coupling of Propiolic Acids with Secondary Amines and Aldehydes.

An efficient microwave-assisted synthesis of tertiary propargylamines has been developed by copper(I)-catalyzed decarboxylative A³-coupling reaction of an alkynylcarboxylic acid with a secondary amine and an aldehyde. A wide range of diversely substituted propargylamines could be synthesized in high yields. The optimal reaction conditions are also effective for 3-alkylpropiolic acids and for terminal propiolic acid. [ABSTRACT FROM AUTHOR]