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Adoptive Transfer of EBV Specific CD8+ T Cell Clones Can Transiently Control EBV Infection in Humanized Mice.
- Source :
- PLoS Pathogens; Aug2014, Vol. 10 Issue 8, p1-14, 14p
- Publication Year :
- 2014
-
Abstract
- Epstein Barr virus (EBV) infection expands CD8<superscript>+</superscript> T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8<superscript>+</superscript> T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8<superscript>+</superscript> T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8<superscript>+</superscript> T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
ANTIGENS
B cells
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 10
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 97810694
- Full Text :
- https://doi.org/10.1371/journal.ppat.1004333