Back to Search
Start Over
Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals.
- Source :
- PLoS Pathogens; Aug2014, Vol. 10 Issue 8, p1-13, 13p
- Publication Year :
- 2014
-
Abstract
- A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated (“putative progressors”, PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (T<subscript>SCM</subscript> (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = −0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (T<subscript>CM</subscript>) cells (p = 0.035), and the total number of T<subscript>CM</subscript> cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ T<subscript>CM</subscript> and T<subscript>SCM</subscript>, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
VIREMIA
HIV infections
STEM cell research
CD4 antigen
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 10
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 97810701
- Full Text :
- https://doi.org/10.1371/journal.ppat.1004345