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Preparation and characterization of kasuga-silica-conjugated nanospheres for sustained antimicrobial activity.
- Source :
- Journal of Nanoparticle Research; Nov2014, Vol. 16 Issue 11, p1-10, 10p
- Publication Year :
- 2014
-
Abstract
- Controlled release formulation of pesticides is highly desirable for attaining the most effective utilization of the pesticide as well as reducing environmental pollution. Nano-sized controlled release formulations can provide better penetration through cuticle and deliver the active ingredients efficiently to the targeted tissue. In this study, a novel strategy for the preparation of a nanoconjugate derived from kasugamycin with amino-modified silica was developed. The kasugamycin was connected with amino-modified silica matrix by an amide bond, which could avoid the initial burst release effectively and prolong the duration remarkably. The results showed the kasuga-silica can protect kasugamycin against photo-degradation effectively and the release rate of the active ingredient of nanoconjugate was related to the temperature, pH value, and the particle size (52.5-315.4 nm). With reduced particle size as well as increased temperature and acidity, the release of the active ingredient was faster. This amide linkage of kasuga-silica could be degraded by amidase effectively. This nanoconjugate displayed a better and a sustained bactericidal efficacy against E. coli than kasugamycin technical, which makes it a potential candidate as a controlled release conjugate for kasugamycin in the future. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13880764
- Volume :
- 16
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Nanoparticle Research
- Publication Type :
- Academic Journal
- Accession number :
- 98742855
- Full Text :
- https://doi.org/10.1007/s11051-014-2671-0