An efficient three-component synthesis of trispiropyrrolidines derivatives through 1,3-dipolar cycloaddition reaction.

The synthesis of novel trispiropyrrolidine derivatives has been achieved by a one-pot, three-component 1,3-dipolar cycloaddition reaction of 3-aryl-5-arylmethylenespiro[indole-3′,2-[1,3]thiazolane]-2′(1H),4-dione, isatin and sarcosine in refluxing toluene which produced the corresponding cycloadducts in good yields. The structures were determined by ¹ H NMR, IR and elementary analysis. [ABSTRACT FROM AUTHOR]