Modeling hologenome imbalances in inflammation and cancer.

The authors discuss the hologenome imbalances modeling in cancer and inflammation. Topics of opinion and review articles mentioned are adaptation of Koch's postulates in assessing the causation between intestinal disease in cancer patients and pathogen pseudomonas aeruginosa, the role of microbiota on exacerbation of cancer and intestinal inflammation, and the role of innate immunity, stress, and inflammatory signaling pathways in tumorigenesis and intestinal stem cell proliferation.