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Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer.
- Source :
- Tumor Biology (Springer Science & Business Media B.V.); Oct2014, Vol. 35 Issue 10, p10075-10084, 10p
- Publication Year :
- 2014
-
Abstract
- MicroRNAs (miRNAs) are known to mainly target protein-coding genes at post-transcriptional level, resulting in mRNA destabilization and/or translational repression. Long non-coding RNAs (lncRNAs) are emerging as a novel set of targets for miRNAs. Here, we report that downregulated hsa-miR-1 and upregulated lncRNA urothelial cancer associated 1 (UCA1) were inversely expressed in bladder cancer. Hsa-miR-1 decreased the expression of UCA1 in bladder cancer cells in an Ago2-slicer-dependent manner. The binding site between UCA1 and hsa-miR-1 was confirmed. Overexpression of hsa-miR-1 inhibited bladder cancer cell growth, induced apoptosis, and decreased cell motility. Knockdown of UCA1 expression phenocopied the effects of upregulation of hsa-miR-1. Transfection of UCA1 expression vector partly reversed the changes caused by transfection of pre-miR-1 plasmids. This study provides evidence for hsa-miR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer, which may have potential therapeutic significance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10104283
- Volume :
- 35
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Tumor Biology (Springer Science & Business Media B.V.)
- Publication Type :
- Academic Journal
- Accession number :
- 99109110
- Full Text :
- https://doi.org/10.1007/s13277-014-2321-2