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Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population.

Authors :
Li-Na Liao
Ching-Chu Chen
Fang-Yang Wu
Cheng-Chieh Lin
Jen-Hao Hsiao
Chwen-Tzuei Chang
Kardia, Sharon L. R.
Tsai-Chung Li
Fuu-Jen Tsai
Source :
BMC Genetics; 2014, Vol. 15 Issue 1, p1-21, 21p
Publication Year :
2014

Abstract

Background Diabetic nephropathy (DN) has become one of the most common causes of end-stage renal disease (ESRD) in many countries, such as 44.5% in Taiwan. Previous studies have shown that there is a genetic component to ESRD. Studies attempting to determine which genetic variants are related to DN in Han Chinese are limited. Results We included 574 unrelated type 2 diabetes patients (217 DN cases and 357 controls), who were genotyped using Illumina HumanHap550-Duo BeadChip. In single-SNP association tests, the SNPs rs11647932, rs11645214, and rs6499323 located at 16q22.1 under the additive-effect disease model were significantly associated with an approximately 2-fold increased risk of DN. In haplotype association tests, identified haplotypes located in the chromosome 16q22.1 region (containing ST3GAL2, COG4, SF3B3, and IL34 genes) raised DN risk. The strongest association was found with haplotype rs2288491-rs4985534- rs11645214 (C-C-G) (adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.83- 2.03, p =6.25 × 10<superscript>-7</superscript>), followed by haplotype rs8052125-rs2288491-rs4985534-rs11645214 (G-C-C-G) (AOR 1.92, 95% CI 1.82-2.02, p =6.56 × 10<superscript>-7</superscript>), and haplotype rs2303792- rs8052125-rs2288491-rs4985534-rs11645214 (A-G-C-C-G) (AOR 1.91, 95% CI 1.81-2.01, p =1.15 × 10<superscript>-6</superscript>). Conclusions Our results demonstrate that the novel SNPs and haplotypes located at the 16q22.1 region may involve in the biological pathways of DN in Han Chinese patients with type 2 diabetes. This study can provide new insights into the etiology of DN. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712156
Volume :
15
Issue :
1
Database :
Complementary Index
Journal :
BMC Genetics
Publication Type :
Academic Journal
Accession number :
99360307
Full Text :
https://doi.org/10.1186/s12863-014-0113-8