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Autophagy is essential for effector CD8+ T cell survival and memory formation.
- Source :
- Nature Immunology; Nov2014, Vol. 15 Issue 12, p1152-1161, 10p, 8 Graphs
- Publication Year :
- 2014
-
Abstract
- The importance of autophagy in the generation of memory CD8<superscript>+</superscript> T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8<superscript>+</superscript> T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8<superscript>+</superscript> T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 15
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 99463589
- Full Text :
- https://doi.org/10.1038/ni.3025