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Treatment and Outcome of Patients with Skull Base Chordoma: A Meta-analysis.
- Source :
- Journal of Neurological Surgery. Part B. Skull Base; 2014, Vol. 75 Issue 6, p383-390, 8p
- Publication Year :
- 2014
-
Abstract
- Objective Chordoma is a locally aggressive tumor. The aim of this study was to assess the efficacy of different surgical approaches and adjuvant radiation modalities used to treat these patients. Design Meta-analysis. Main Outcome Measures Overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS). Results The 5-year OS and PFS rates of the whole cohort (n=467) were 86% and 65.7%, respectively. The 5-year DSS for patients who underwent open surgery and endoscopic surgery was 45% and 49%, respectively (p=0.8); PFS was 94% and 79%, respectively (p=0.11). The 5-year OS of patients treated with surgery followed by adjuvant radiotherapy was 90% compared with 70% of those treated by surgery alone (p=0.24). Patients undergoing partial resection without adjuvant radiotherapy had a 5-year OS of 41% and a DSS of 45%, significantly lower than in the total-resection group (p = 0.0002 and p = 0.01, respectively). The complication rates were similar in the open and endoscopic groups. Conclusions Patients undergoing total resection have the best outcome; adjuvant radiation therapy improves the survival of patients undergoing partial resection. In view of the advantages of minimally invasive techniques, endoscopic surgery appears an appropriate surgical approach for this disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21936331
- Volume :
- 75
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Neurological Surgery. Part B. Skull Base
- Publication Type :
- Academic Journal
- Accession number :
- 99607864
- Full Text :
- https://doi.org/10.1055/s-0034-1376197