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ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.
- Source :
- British Journal of Haematology; Jan2015, Vol. 168 Issue 1, p139-142, 4p, 2 Graphs
- Publication Year :
- 2015
-
Abstract
- The article presents a study on correlation of ZAP70 protein expression with the disease chronic lymphocytic leukemia (CLL). It states the analyses of ZAP70 expression in CLL cells and its role in altering B cells which further promotes stromal cell adhesion. It mentions that ZAP70 proteins can alter B cells by affecting its signaling pathways either by its kinase or adaptor functions.
- Subjects :
- CHRONIC lymphocytic leukemia
PROTEIN expression
STROMAL cells
B cells
CELL adhesion
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 168
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 99885293
- Full Text :
- https://doi.org/10.1111/bjh.13063