Accumulation of adverse prognostic markers worsens prognosis in chronic lymphocytic leukaemia.

The article presents a study on role of negative prognostic markers in prognosis of chronic lymphocytic leukemia (CLL). It states that the study analyzed a group of CLL patients without prior treatments to determine the affect of prognostic markers in the disease. The authors mentions correlation between immunoglobulin heavy (IGHV) mutational status and biochemical markers. They state that several markers such as SF3B1mut were found worsening the course of prognosis in CLL patients.