Synthesis of ( E)-1,4-Enediones from α-Halo Ketones Through a Sodium Sulfinate Mediated Reaction.

We developed a mild and practical protocol for the synthesis of 1,4-enedione from α-halo ketones through a sodium sulfinate mediated reaction. This reaction enables the construction of symmetric and unsymmetric 1,4-enedione with complete E selectivity. Sodium 4-toluenesulfinate plays an important role in this reaction. [ABSTRACT FROM AUTHOR]