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Diagnosis of upper tract urothelial carcinoma—a comparative study of urinary cytology and surgical biopsy.

Authors :
Wang, Lu
Pambuccian, Stefan E.
Wojcik, Eva M.
Barkan, Güliz A.
Source :
Journal of the American Society of Cytopathology; Jan2015, Vol. 4 Issue 1, p3-9, 7p
Publication Year :
2015

Abstract

Introduction Upper tract urothelial carcinoma (UTUC) is defined as urothelial carcinoma (UC) arising in the renal pelvis and ureter. Upper tract (UT) cytology and biopsy evaluation can be technically challenging. The aim of the study is to evaluate the diagnostic modality and sensitivity of urine cytology and ureteroscopic biopsy for the diagnosis of UTUC. Material and methods All patients with UTUC who underwent radical nephroureterectomy or ureterectomy with preoperative cytology and/or biopsy from January 1, 2000 to September 30, 2011 at our institution were included in this study. The sensitivity of each diagnostic modality was calculated with respect to tumor grade, stage, and size. Results A total of 143 cytology specimens and 54 biopsies from 65 patients were evaluated. For low-grade UTUC, the sensitivities for biopsy, lower tract cytology, and UT cytology were 68.4%, 27.3%, and 37.5%, respectively. These numbers were 82.9%, 40.7%, and 80.6% for high-grade UTUC. By combining the UT cytology and biopsy, the diagnostic sensitivities were increased to 87.5% for low-grade UTUC and 100% for high-grade UTUC. The consistency of tumor grade between biopsy and surgical specimen were 63.2% for low-grade UTUC and 68.6% for high-grade UTUC. Conclusions Both UT cytology and biopsy showed higher sensitivity in detecting high-grade UTUC versus low-grade UTUC. The sensitivities of UT cytology and ureteroscopic biopsy in detecting high-grade UTUC were comparable. The sensitivity was greatly improved when these diagnostic modalities were combined. As expected, the selective UT cytology evaluation had superior sensitivity in detecting UTUC than did the lower tract cytology sampling. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22132945
Volume :
4
Issue :
1
Database :
Supplemental Index
Journal :
Journal of the American Society of Cytopathology
Publication Type :
Academic Journal
Accession number :
100062622
Full Text :
https://doi.org/10.1016/j.jasc.2014.09.203