Pharmacogenomic Determinants of the Cardiovascular Effects of Dalcetrapib.

Authors :: Tardif, Jean-Claude
Rhéaume, Eric
Lemieux Perreault, Louis-Philippe
Grégoire, Jean C.
Zada, Yassamin Feroz
Asselin, Géraldine
Provost, Sylvie
Barhdadi, Amina
Rhainds, David
L'Allier, Philippe L.
Ibrahim, Reda
Upmanyu, Ruchi
Niesor, Eric J.
Benghozi, Renée
Suchankova, Gabriela
Laghrissi-Thode, Fouzia
Guertin, Marie-Claude
Olsson, Anders G.
Mongrain, Ian
Schwartz, Gregory G.
Source :: Circulation: Cardiovascular Genetics; Apr2015, Vol. 8 Issue 2, p372-382, 11p
Publication Year :: 2015
Abstract: The article discusses a research which examines the pharmacogenomic determinants of the effects of dalcetrapib on cardiovascular disease outcomes. It reveals that a single nucleotide polymorphism was associated with cardiovascular events in the dalcetrapib arm. It indicates that the cardiovascular effects of dalcetrapib are determined by correlated single nucleotide polymorphisms in the ADCY9 gene on chromosome 16.