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The association of ICAM E469K with cardiovascular characteristics of acromegaly.

Authors :
OGUZ, E.
TABUR, S.
AKBAS, H.
DUZEN, I. V.
KARABAG, H.
AKKAFA, F.
OZKAYA, M.
ALASEHIRLI, B.
Source :
European Review for Medical & Pharmacological Sciences; May2015, Vol. 19 Issue 9, p1673-1679, 7p
Publication Year :
2015

Abstract

OBJECTIVE: It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients. PATIENTS AND METHODS: We included 41 patients with acromegaly and 65 healthy subjects with similar age and sex to the study. Fasting plasma glucose (FPG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG) were analyzed. Genotyping was made by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The frequency of genotype and allel ICAM-1 E469K was not significantly different between control and patients (p > 0.05). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG levels were significantly higher, and HDL-C was significantly lower in patients with KK genotypes compared to patients with EE genotype in acromegaly group (p < 0.05). CONCLUSIONS: This is the first study to investigate the role of ICAM gene polymorphism in acromegaly and its cardiovascular characteristics. ICAM E469K may not be a risk factor for the acromegaly in Turkish population but may be associated with hypertension, higher FPG and lower HDL-C in acromegalic patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11283602
Volume :
19
Issue :
9
Database :
Supplemental Index
Journal :
European Review for Medical & Pharmacological Sciences
Publication Type :
Academic Journal
Accession number :
102768432