A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age.

The article discusses the genome-wide association study on early-onset breast cancer (EOBC), that found breast cancer to be associated with the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11. Topics discussed include association of 32 of the 82 known later-onset breast cancer (LOBC) single-nucleotide polymorphisms (SNP) with EOBC, apparently similar genetic etiologies for EOBC and LOBC, and possibility of 5q11.2 region containing multiple distinct breast cancer loci.