Gene Variants in Angiogenesis and Lymphangiogenesis and Cutaneous Melanoma Progression.

The article presents the study which examined the relationship between 238 single-nucleotide polymorphisms (SNP) in 26 angiogenesis and lymphangiogenesis genes in the progression of melanoma and the risk of sentinel lymph node (SLN) metastasis and mortality. Also cited are the common prognostic features of melanoma including tumor thickness, ulceration, and mitotic rate. The study examined data provided by the Moffitt Cancer Center in Tampa, Florida.