Breast Cancer Risk Associated with Estrogen Exposure and Truncating Mutation Location in BRCA1/2 Carriers.

Authors :: Lecarpentier, Julie
Noguès, Catherine
Mouret-Fourme, Emmanuelle
Buecher, Bruno
Gauthier-Villars, Marion
Stoppa-Lyonnet, Dominique
Bonadona, Valèrie
Fricker, Jean-Pierre
Berthet, Pascaline
Caron, Olivier
Coupier, Isabelle
Pujol, Pascal
Faivre, Laurence
Gesta, Paul
Eisinger, François
Mari, Vèronique
Gladieff, Laurence
Lortholary, Alain
Luporsi, Elisabeth
Leroux, Dominique
Source :: Cancer Epidemiology, Biomarkers & Prevention; Apr2015, Vol. 24 Issue 4, p698-707, 10p
Publication Year :: 2015
Abstract: The article discusses a study related to relation between estrogen exposure and truncating mutation location in BRCA1/2 Carriers as a risk factor for breast cancer. It states that a genotype-phenotype correlation has been found in both genes, and the effect of reproductive factors differs according to mutation location.

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