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Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.
Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.
- Source :
- Journal of Cardiac Failure; May2008, Vol. 14 Issue 4, p327-335, 9p
- Publication Year :
- 2008
-
Abstract
- <bold>Background: </bold>It is not known how carbohydrate and fat intake affect the development of left ventricular (LV) hypertrophy and contractile dysfunction in response to pressure overload. We hypothesized that a low-carbohydrate/high-fat diet prevents LV hypertrophy and dysfunction compared with high-carbohydrate diets.<bold>Methods and Results: </bold>Rats were fed high-carbohydrate diets composed of either starch or sucrose, or a low-carbohydrate/high-fat diet, and underwent abdominal aortic banding (AAB) for 2 months. AAB increased LV mass with all diets. LV end-diastolic and systolic volumes and the ratio of the mRNA for myosin heavy chain beta/alpha were increased with both high-carbohydrate diets but not with the low-carbohydrate/high-fat diet. Circulating levels of insulin and leptin, both stimulants for cardiac growth, were lower, and free fatty acids were higher with the low-carbohydrate/high-fat diet compared with high-carbohydrate diets. Among animals that underwent AAB, LV volumes were positively correlated with insulin and LV mass correlated with leptin.<bold>Conclusion: </bold>A low-carbohydrate/high-fat diet attenuated pressure overload-induced LV remodeling compared with high-carbohydrate diets. This effect corresponded to lower insulin and leptin concentrations, suggesting they may contribute to the development of LV hypertrophy and dysfunction under conditions of pressure overload. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10719164
- Volume :
- 14
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Cardiac Failure
- Publication Type :
- Academic Journal
- Accession number :
- 105776195
- Full Text :
- https://doi.org/10.1016/j.cardfail.2007.11.003