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Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

Authors :
Duda MK
O'Shea KM
Lei B
Barrows BR
Azimzadeh AM
McElfresh TE
Hoit BD
Kop WJ
Stanley WC
Duda, Monika K
O'Shea, Karen M
Lei, Biao
Barrows, Brian R
Azimzadeh, Agnes M
McElfresh, Tracy E
Hoit, Brian D
Kop, Willem J
Stanley, William C
Source :
Journal of Cardiac Failure; May2008, Vol. 14 Issue 4, p327-335, 9p
Publication Year :
2008

Abstract

<bold>Background: </bold>It is not known how carbohydrate and fat intake affect the development of left ventricular (LV) hypertrophy and contractile dysfunction in response to pressure overload. We hypothesized that a low-carbohydrate/high-fat diet prevents LV hypertrophy and dysfunction compared with high-carbohydrate diets.<bold>Methods and Results: </bold>Rats were fed high-carbohydrate diets composed of either starch or sucrose, or a low-carbohydrate/high-fat diet, and underwent abdominal aortic banding (AAB) for 2 months. AAB increased LV mass with all diets. LV end-diastolic and systolic volumes and the ratio of the mRNA for myosin heavy chain beta/alpha were increased with both high-carbohydrate diets but not with the low-carbohydrate/high-fat diet. Circulating levels of insulin and leptin, both stimulants for cardiac growth, were lower, and free fatty acids were higher with the low-carbohydrate/high-fat diet compared with high-carbohydrate diets. Among animals that underwent AAB, LV volumes were positively correlated with insulin and LV mass correlated with leptin.<bold>Conclusion: </bold>A low-carbohydrate/high-fat diet attenuated pressure overload-induced LV remodeling compared with high-carbohydrate diets. This effect corresponded to lower insulin and leptin concentrations, suggesting they may contribute to the development of LV hypertrophy and dysfunction under conditions of pressure overload. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10719164
Volume :
14
Issue :
4
Database :
Supplemental Index
Journal :
Journal of Cardiac Failure
Publication Type :
Academic Journal
Accession number :
105776195
Full Text :
https://doi.org/10.1016/j.cardfail.2007.11.003