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Efficacy of a Chinese herbal medicine for the treatment of atopic dermatitis: a randomised controlled study.
- Source :
- Complementary Therapies in Medicine; Oct2015, Vol. 23 Issue 5, p644-651, 8p
- Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>More randomised control trials are required to assess the efficacy of traditional Chinese medicine. This multi-centre, randomised, assessor-blind, controlled study assessed the efficacy of the Chinese herbal formula Pei Tu Qing Xin Tang (PTQXT) for treating patients with atopic dermatitis (AD).<bold>Methods: </bold>Patients aged 5-25 years with moderate-to-severe AD were randomised to receive a 12-week treatment involving either oral administration of PTQXT; oral administration of PTQXT combined with an external application of Chinese herbs; or oral administration of antihistamine and a placebo of PTQXT pills added to topical 1% mometasone furoate. The primary end-point measure was the change in the Scoring Atopic Dermatitis Index (SCORAD) at the end of the observation period, and secondary end-points included quality of life (QOL). The outcomes were evaluated at baseline, then every 4 weeks from week 4 to week 12 and every 8 weeks from week 12 to week 36.<bold>Results: </bold>Two hundred and seventy-five patients were recruited. During the 12-week treatment period, up to the primary end-point, the mean SCORAD decreased gradually in all three groups. At week 28 and week 36, there was a significantly greater decrease in the mean SCORAD for the Chinese herbal medicine-treated groups than for the control group (at week 28, P=0.002 and P=0.036, respectively; at week 36, P<0.001 and P=0.002, respectively). At week 36, the difference in QOL scores showed a significantly greater improvement in both Chinese herbal medicine-treated groups than in the control group (P<0.001 and P<0.001, respectively).<bold>Conclusions: </bold>PTQXT is effective in decreasing the severity of the disease and improving the QOL in patients with moderate-to-severe AD.<bold>Trial Registration: </bold>Chinese Clinical Trial Registry: ChiCTR-TRC-08000156. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09652299
- Volume :
- 23
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Complementary Therapies in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 110384335
- Full Text :
- https://doi.org/10.1016/j.ctim.2015.07.006