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Plasma heat shock protein 27 is increased in renal dysfunction and habitual smoking in a Japanese general population.

Authors :
Nakayoshi, Takaharu
Adachi, Hisashi
Ohbu-Murayama, Kyoko
Enomono, Mika
Fukami, Ako
Kumagai, Eita
Nakamura, Sachiko
Nohara, Yume
Nakao, Erika
Sasaki, Ken-ichiro
Fukumoto, Yoshihiro
Source :
Journal of Cardiology; Jan2016, Vol. 67 Issue 1, p110-114, 5p
Publication Year :
2016

Abstract

Background Heat shock proteins (HSPs) work as “chaperones” to affect protein folding of newly synthesized or denatured proteins. HSP 27 plays an important role in coronary artery disease or renal disease as the result of oxidative stress. Although habitual smoking is well known to induce oxidative stress, there is no epidemiological evidence between plasma HSP 27 and renal dysfunction or smoking habits. Methods A total of 451 residents (167 men and 284 women, age 65.7 years) underwent a history and physical examination, and determination of blood chemistries, including plasma levels of HSP 27. HSP 27 levels were measured by using enzyme-linked immunosorbent assay kits. Results Elevated HSP 27 levels were independently associated with estimated glomerular filtration rate (eGFR) ( p < 0.001) and smoking habits ( p < 0.05). HSP 27 levels were significantly decreased stratified by groups of eGFR ( p < 0.001 for trend) by analysis of co-variance (ANCOVA) adjusted for age, sex, and smoking habits. HSP 27 levels were increased with more smoking of cigarettes. In particular, HSP 27 levels were increased in the heavy smokers (≥20 cigarettes/day) by ANCOVA adjusted for age, sex, and eGFR compared with non-smokers and light smokers ( p < 0.05 for trend). Conclusions The present study demonstrated that HSP 27 levels were strongly related to renal dysfunction and habitual smoking in a dose–response manner in a Japanese general population. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09145087
Volume :
67
Issue :
1
Database :
Supplemental Index
Journal :
Journal of Cardiology
Publication Type :
Academic Journal
Accession number :
111877804
Full Text :
https://doi.org/10.1016/j.jjcc.2015.04.005