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De-novo donor-specific antibody (DSA) against HLA-DQ antigens resulting in acute antibody mediated rejection in a renal transplant patient.
- Source :
- Clinical Queries Nephrology; Jan2016, Vol. 5 Issue 1, p1-3, 3p
- Publication Year :
- 2016
-
Abstract
- A highly sensitive single antigen bead assay (SAB) by luminex is a very useful tool for post-transplant monitoring of HLA antibodies for diagnosing antibody-mediated rejection ABMR. Donor-specific anti-HLA antibodies that arise de-novo (de-novo DSA) after transplantation, indicate the highest risk for acute antibody-mediated rejection (AMR) and graft loss. The return of pre-existing antibodies after transplantation or the development of new de-novo anti-HLA or non-HLA DSA may also confer an increased risk for graft loss. A case with de-novo donor-specific antibody (DSA) against HLA-DQ antigens resulting in acute antibody-mediated rejection (ABMR) in a renal transplant patient is presented along with review of literature. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22119477
- Volume :
- 5
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Clinical Queries Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 115413022
- Full Text :
- https://doi.org/10.1016/j.cqn.2016.04.002