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Approaches to preventative and therapeutic HIV vaccines.
- Source :
- Current Opinion in Virology; Apr2016, Vol. 17, p104-109, 6p
- Publication Year :
- 2016
-
Abstract
- Novel strategies are being researched to discover vaccines to prevent and treat HIV-1. Non-efficacious preventative vaccine approaches include bivalent recombinant gp120 alone, HIV gene insertion into an Adenovirus 5 (Ad5) virus vector and the DNA prime/Ad5 boost vaccine regimen. However, the ALVAC-HIV prime/AIDSVAX® B/E gp120 boost regimen showed 31.2% efficacy at 3.5 years, and is being investigated as clade C constructs with an additional boost. Likewise, although multiple therapeutic vaccines have failed in the past, in a non-placebo controlled trial, a Tat vaccine demonstrated immune cell restoration, reduction of immune activation, and reduced HIV-1 DNA viral load. Monoclonal antibodies for passive immunization or treatment show promise, with VRC01 entering advanced clinical trials. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18796257
- Volume :
- 17
- Database :
- Supplemental Index
- Journal :
- Current Opinion in Virology
- Publication Type :
- Academic Journal
- Accession number :
- 116378892
- Full Text :
- https://doi.org/10.1016/j.coviro.2016.02.010