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Serum and Wound Vancomycin Levels After Intrawound Administration in Primary Total Joint Arthroplasty.
- Source :
- Journal of Arthroplasty; Mar2017, Vol. 32 Issue 3, p924-928, 5p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Periprosthetic joint infection is the most common cause of readmissions after total joint arthroplasty (TJA). Intrawound vancomycin powder (VP) has reduced infection rates in spine surgery; however, there are no data regarding VP in primary TJA.<bold>Methods: </bold>Thirty-four TJA patients received 2 g of VP intraoperatively to investigate VP's pharmacokinetics. Serum and wound concentrations were measured at multiple intervals over 24 hours after closure.<bold>Results: </bold>All serum concentrations were subtherapeutic (<15μg/mL) and peaked 12 hours after closure (4.7μg/mL; standard deviation [SD], 3.2). Wound concentrations were 922 μg/mL (SD, 523) 3 hours after closure and 207 μg/mL (SD, 317) at 24 hours. VP had a half-life of 7.2 hours (95% confidence interval, 7.0-9.3) in TJA wounds.<bold>Conclusions: </bold>VP produced highly therapeutic intrawound concentrations while yielding low systemic levels in TJA. VP may serve as a safe adjunct in the prevention of periprosthetic joint infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08835403
- Volume :
- 32
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Arthroplasty
- Publication Type :
- Academic Journal
- Accession number :
- 121220557
- Full Text :
- https://doi.org/10.1016/j.arth.2015.10.015