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Vitamin D Deficiency and Metabolism in HIV-Infected and HIV-Uninfected Men in the Multicenter AIDS Cohort Study.
- Source :
- AIDS Research & Human Retroviruses; Mar2017, Vol. 33 Issue 3, p261-270, 10p
- Publication Year :
- 2017
-
Abstract
- We evaluated associations of serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]<subscript>2</subscript>D) levels in a cohort of HIV-infected and HIV-uninfected men at risk for infection in the United States. Stored samples collected between 1999 and 2008 were tested for vitamin D metabolites between 2014 and 2015. Vitamin D deficiency was defined as a serum concentration of 25[OH]D <20 ng/ml. Multivariate models were used to assess associations of various demographic and clinical factors with vitamin D status. HIV-infected men on effective antiretroviral therapy ( n = 640) and HIV-uninfected men ( n = 99) had comparable levels of 25[OH]D and 1,25[OH]<subscript>2</subscript>D, and prevalences of vitamin D deficiency were 41% in HIV-infected and 44% in HIV-uninfected men, respectively. Self-reported black or other non-white race, obesity, and normal kidney function were significant predictors of vitamin D deficiency regardless of HIV serostatus. Lower CD4<superscript>+</superscript> T cell count was associated with vitamin D deficiency in HIV-infected men, while current ritonavir use was protective. Self-reported black race was the only factor significantly associated with higher levels of 1,25[OH]<subscript>2</subscript>D (vs. whites; β = 4.85 pg/ml, p = .003). Levels of 1,25[OH]<subscript>2</subscript>D and 25[OH]D were positively correlated in HIV-infected men ( β = 0.32 pg/ml, p < .001), but not in uninfected men ( β = −0.09 pg/ml, p = .623; p < .05 for interaction). Vitamin D deficiency was prevalent regardless of HIV serostatus in this cohort, suggesting that HIV infection did not confer additional risk of deficiency in this cohort of well-treated HIV-infected men. However, HIV infection and race may have implications for vitamin D metabolism and 1,25[OH]<subscript>2</subscript>D levels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08892229
- Volume :
- 33
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- AIDS Research & Human Retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 121501942
- Full Text :
- https://doi.org/10.1089/aid.2016.0144