Preoperative Coil Embolization of Side Branches and Postoperative Antifibrinolytic Therapy in Endovascular Aneurysm Repair: A Propensity Score Analysis.

<bold>Purpose: </bold>To demonstrate feasibility and efficacy of preoperative coil embolization of side branches and postoperative tranexamic acid (TXA) therapy for management of type II endoleak and aneurysmal sac regression after endovascular aortic repair (EVAR).<bold>Materials and Methods: </bold>This study included 284 patients who underwent EVAR between 2007 and 2014. In 133 patients (group A), since March 2012, preoperative coil embolization of side branches and postoperative TXA therapy had been introduced as a modified strategy after EVAR, including combined coil embolization and TXA therapy (n = 41), coil embolization only (n = 17), and TXA therapy only (n = 75). The remaining 151 patients (group B) underwent EVAR with no coil embolization and TXA therapy. After propensity score matching, postoperative results were retrospectively compared between 92 matched pairs (group A vs group B).<bold>Results: </bold>Matched comparison revealed no significant difference in incidence rate of type II endoleak at 6 months after EVAR between group A and group B (19.6% [18/92] vs 29.4% [27/92]; P = .1172). A significantly greater shrinkage of sac size at 6 months after EVAR (-8.5% ± 11.6 vs -3.6% ± 8.4; P = .0011) and significantly more rapid pace of sac shrinkage (change of size per year; -4.2 mm/y ± 7.6 vs -1.9 mm/y ± 6.1; P = .0301) were observed in group A.<bold>Conclusions: </bold>Combined preoperative coil embolization of side branches and postoperative TXA therapy were associated with significantly more rapid aneurysmal sac regression after EVAR. [ABSTRACT FROM AUTHOR]