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Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration.

Authors :
Heller, Julia
Brcina, Nikolina
Dogan, Imis
Holtbernd, Florian
Romanzetti, Sandro
Schulz, Jörg B.
Schiefer, Johannes
Reetz, Kathrin
Source :
Sleep Medicine Reviews; Aug2017, Vol. 34, p23-33, 11p
Publication Year :
2017

Abstract

Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of physiological atonia of skeletal muscles with abnormal behavior during dream sleep. RBD may be the initial manifestation of neurodegenerative diseases, particularly of α-synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). However, gauging the individual risk of subsequent phenoconversion and making assumptions on the type of disease that may subsequently follow RBD is challenging. Over the past years, a growing number of studies have sought to establish reliable neuroimaging markers to detect neurodegenerative brain changes in RBD subjects at the earliest possible stage. The present review summarizes recent advances in brain imaging in RBD and provides recommendations for the application of currently available structural and functional neuroimaging modalities to monitor disease progression and risk of subsequent phenoconversion. Further imaging research applying multimodal approaches is encouraged to enhance accuracy of prognoses. Additionally, more longitudinal studies are warranted to validate findings from cross-sectional studies on RBD progression and risk of subsequent phenoconversion. Aside from enabling reliable prognoses on a single-subject-level in the near future, this might give further insight into RBD pathophysiology, and finally augment the development of intervention strategies and disease-modifying therapies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10870792
Volume :
34
Database :
Supplemental Index
Journal :
Sleep Medicine Reviews
Publication Type :
Academic Journal
Accession number :
124047985
Full Text :
https://doi.org/10.1016/j.smrv.2016.06.006