Back to Search
Start Over
Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads.
- Source :
- Journal of Pediatrics; Aug2017, Vol. 187, p147-152.e1, 1p
- Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>To examine the association between maternal body mass index (BMI) and serum 25-hydroxy vitamin D [25(OH)D] concentration and bone density in mother-infant pairs.<bold>Study Design: </bold>The study was a secondary analysis of 234 exclusively breastfeeding dyads who were recruited in the first postpartum month for a randomized controlled trial of maternal vs infant vitamin D supplementation. Mean 25(OH)D concentrations and bone mineral density (BMD) were compared by BMI group. The adjusted association between maternal BMI and 25(OH)D and bone density was examined at 1, 4, and 7 months postpartum.<bold>Results: </bold>Obese breastfeeding women had lower 25(OH)D concentrations and higher BMD than lean women at all 3 time points (P < .01). Higher maternal BMI was associated with lower maternal serum levels of 25(OH)D at 1, 4, and 7 months postpartum (adjusted β = -0.45 ng/ml per kg/m2, 95% CI -.076, -0.14, at 1 month) and higher BMD at the same time points (β = 0.006 BMD z score; 95% CI 0.003, 0.01 at 1 month). Seventy-six percent of infants were vitamin D deficient at 1 month of age. Infants born to overweight and obese mothers had lower 25(OH)D concentrations than infants of lean mothers (P < .01). For infants in the maternal supplementation group, higher maternal BMI was associated with lower 25(OH)D concentrations at 4 months (β = -0.68; 95% CI -1.17, -0.20) and lower bone density at 7 months (β = -0.001; 95% CI -0.002, -0.0001).<bold>Conclusions: </bold>In exclusively breastfeeding dyads, maternal obesity is associated with lower maternal and infant serum 25(OH)D concentrations, which may impact infant bone density.<bold>Trial Registration: </bold>ClinicalTrials.gov: NCT00412074. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223476
- Volume :
- 187
- Database :
- Supplemental Index
- Journal :
- Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 124140109
- Full Text :
- https://doi.org/10.1016/j.jpeds.2017.04.024