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Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads.

Authors :
Sen, Sarbattama
Penfield-Cyr, Annie
Hollis, Bruce W.
Wagner, Carol L.
Source :
Journal of Pediatrics; Aug2017, Vol. 187, p147-152.e1, 1p
Publication Year :
2017

Abstract

<bold>Objective: </bold>To examine the association between maternal body mass index (BMI) and serum 25-hydroxy vitamin D [25(OH)D] concentration and bone density in mother-infant pairs.<bold>Study Design: </bold>The study was a secondary analysis of 234 exclusively breastfeeding dyads who were recruited in the first postpartum month for a randomized controlled trial of maternal vs infant vitamin D supplementation. Mean 25(OH)D concentrations and bone mineral density (BMD) were compared by BMI group. The adjusted association between maternal BMI and 25(OH)D and bone density was examined at 1, 4, and 7 months postpartum.<bold>Results: </bold>Obese breastfeeding women had lower 25(OH)D concentrations and higher BMD than lean women at all 3 time points (P  <  .01). Higher maternal BMI was associated with lower maternal serum levels of 25(OH)D at 1, 4, and 7 months postpartum (adjusted β = -0.45 ng/ml per kg/m2, 95% CI -.076, -0.14, at 1 month) and higher BMD at the same time points (β = 0.006 BMD z score; 95% CI 0.003, 0.01 at 1 month). Seventy-six percent of infants were vitamin D deficient at 1 month of age. Infants born to overweight and obese mothers had lower 25(OH)D concentrations than infants of lean mothers (P < .01). For infants in the maternal supplementation group, higher maternal BMI was associated with lower 25(OH)D concentrations at 4 months (β = -0.68; 95% CI -1.17, -0.20) and lower bone density at 7 months (β = -0.001; 95% CI -0.002, -0.0001).<bold>Conclusions: </bold>In exclusively breastfeeding dyads, maternal obesity is associated with lower maternal and infant serum 25(OH)D concentrations, which may impact infant bone density.<bold>Trial Registration: </bold>ClinicalTrials.gov: NCT00412074. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00223476
Volume :
187
Database :
Supplemental Index
Journal :
Journal of Pediatrics
Publication Type :
Academic Journal
Accession number :
124140109
Full Text :
https://doi.org/10.1016/j.jpeds.2017.04.024