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Increased Serum 25(OH)D3 Levels in Post-Menopausal Japanese Women with Osteoporosis after 3-Year Bisphosphonate Treatment.
- Source :
- Tohoku Journal of Experimental Medicine; Jul2017, Vol. 242 Issue 3, p241-246, 6p
- Publication Year :
- 2017
-
Abstract
- Osteoporosis is characterized by the systemic impairment of bone mass, strength, and microarchitecture, leading to an increased risk of fragility fracture. Bisphosphonates (BPs) are the first-line drugs for osteoporosis. Vitamin D is considered to be essential for osteoporotic treatment. However, long-term effects of BPs on the serum levels of 25-hydroxyvitamin D<subscript>3</subscript> (25(OH)D<subscript>3</subscript>) are unknown. Accordingly, in this retrospective study, we collected clinical data of 41 post-menopausal Japanese women with osteoporosis treated with BP for over 3 years, without vitamin D supplementation. We measured lumbar and femoral neck bone mineral density (BMD) and serum levels of bone specific alkaline phosphatase (BAP) as a bone formation marker, and tartrate-resistant acid phosphatase (TRACP)-5b as a bone resorption marker, before and after the 3-year treatment. Serum 25(OH)D<subscript>3</subscript>, 1,25(OH)2D<subscript>3</subscript>, and whole parathyroid hormone (PTH) were also measured. Notably, no fracture occurred during the treatment. Compared with baseline values, 25(OH)D<subscript>3</subscript> levels were significantly increased from 21.6 to 26.4 ng/mL (P = 0.006), despite no vitamin D supplementation. 1,25(OH)<subscript>2</subscript>D<subscript>3</subscript> and whole PTH levels tended to be decreased from 62.6 to 57.8 pg/mL and 27.3 to 25.1 pg/mL, respectively. Both bone formation and resorption markers were significantly suppressed (P < 0.01). Both lumbar BMD (7.3% increase) and femoral neck BMD (4.1% increase) were significantly improved (P < 0.0001) after 3 years of the treatment. Thus, even without vitamin D supplementation, serum 25(OH)D<subscript>3</subscript> levels were significantly increased after 3-year BP therapy. These results suggest that vitamin D supplementation might not be required in the long-term BP therapy for osteoporosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00408727
- Volume :
- 242
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Tohoku Journal of Experimental Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 124287339
- Full Text :
- https://doi.org/10.1620/tjem.242.241