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Positron emission tomography modalities prevent futile radical resection of pancreatic cancer: A meta-analysis.
- Source :
- International Journal of Surgery; Oct2017, Vol. 46, p119-125, 7p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Numerous distant metastases were not detected preoperatively. Positron emission tomography (PET) has been used for oncology diagnosis recently. However, it remains controversial whether PET modality is a more efficient way in detecting unresectable features for radical resection of pancreatic cancer (PC). This meta-analysis aims to validate the efficiency of PET modalities (including PET and PET/CT) in preoperative assessment of PC, and compare them with computed tomography (CT).<bold>Methods: </bold>PubMed, EMBASE, Science Citation Index and The Cochrane Library were searched to identify relevant studies. Both PET modality and CT had been performed for all the included patients. A meta-analysis was performed to compare the ability of PET modalities in detecting occult distant metastases and regional lymph nodes invasion with that of CT.<bold>Results: </bold>17 clinical studies that recruited 1343 patients were included. This meta-analysis indicated that PET modalities were more efficient in detecting true positive distant metastases compared with CT (OR = 1.52, 95%CI: 1.23-1.88). In subgroup analysis, when compared with CT alone, PET/CT also showed greater utility in detecting distant metastases (OR = 1.66, 95%CI: 1.31-2.08). There was no definite difference in detecting regional lymph nodes invasion between PET modalities and CT (OR = 0.97, 95%CI: 0.63-1.47).<bold>Conclusion: </bold>Compared with CT, PET/CT provides extensive possibility to avoid futile radical resection by detecting occult metastases of PC preoperatively. Surgeons, especially in developing countries, should take PET modalities as a routine preoperative assessment before making operative plan for PC patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17439191
- Volume :
- 46
- Database :
- Supplemental Index
- Journal :
- International Journal of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 125780240
- Full Text :
- https://doi.org/10.1016/j.ijsu.2017.09.003